发明名称 |
Pharmaceutical Combinations |
摘要 |
A pharmaceutical combination comprising: (a) a phosphatidylinositol-3-kinase inhibitor selected from 5-(2,6-di-morpholin-4-yl-pyrimidin-4-yl)-4-trifluoromethyl-pyridin-2-ylamine, (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or any pharmaceutically acceptable salt thereof and (b) a gonadorelin agonist and, optionally, (c) an antiestrogen agent, particularly for use in the treatment or prevention of a cancer; uses of such a combination in the preparation of a medicament for the treatment or prevention of a cancer; pharmaceutical compositions of the combination of said therapeutic agents and methods of treating a cancer in a subject comprising administering to said subject a therapeutically effective amount of such a combination. |
申请公布号 |
US2016331755(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
US201515109704 |
申请日期 |
2015.01.13 |
申请人 |
Hirawat Samit;Massacesi Cristian |
发明人 |
Hirawat Samit;Massacesi Cristian |
分类号 |
A61K31/5377;A61K31/138;A61K31/4439;A61K38/09 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical combination comprising: (a) a phosphatidylinositol-3-kinase (PI3K) inhibitor selected from 5-(2,6-di-morpholin-4-yl-pyrimidin-4-yl)-4-trifluoromethyl-pyridin-2-ylamine, (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or any pharmaceutically acceptable salt thereof, (b) a gonadorelin agonist, and, optionally, (c) an antiestrogen agent. |
地址 |
Chatham NJ US |