| 主权项 |
1. A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Rb is selected from the group consisting of H, halogen, hydroxyl, cyano and C1-C6 alkyl; R1 is H or C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is selected from the group consisting of H, C1-C6 alkyl, and C(O)OR31; R31 is selected from the group consisting of: C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 alkynyl; C3-C10 cycloalkyl, wherein the C3-C10 cycloalkyl is optionally substituted with from 1-3 independently selected C1-C3 alkyl; —CH2—C3-C10 cycloalkyl wherein the C3-C10 cycloalkyl is optionally substituted with from 1-3 independently selected C1-C3 alkyl; —CH2— phenyl, wherein the phenyl is optionally substituted with from 1-2 substituents independently selected from C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, nitro, halo, SO2Me, cyano, and —OC(O)CH3; and —CH2-pyridyl; R4 and R5 are each independently selected from the group consisting of H, C1-C6 alkyl, X, and —C1-C6 alkylene-X, wherein X is selected from the group consisting of: (i) C3-C6 cycloalkyl; (ii) heteroaryl including from 5 to 6 ring atoms wherein 1, 2, or 3 of the ring atoms are independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; (iii) heterocyclyl including from 3 to 6 ring atoms wherein 1, 2, or 3 of the ring atoms are independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; and (iv) phenyl; wherein C3-C6 cycloalkyl and heterocyclyl are each optionally substituted with from 1-3 substituents independently selected from the group consisting of halogen, cyano, oxo, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy, and —N(R′)R′, wherein R′ is independently selected for each occurrence from H and C1-C6 alkyl; and heteroaryl and phenyl are each optionally substituted with from 1-3 substituents independently selected from the group consisting of halogen, cyano, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy, and —N(R′)R′; or R4 and R5 together with the nitrogen to which they are attached form: heterocyclyl including from 4 to 6 ring atoms; wherein the heterocyclyl includes not more than two ring heteroatoms (including the nitrogen atom attached to R4 and R5), and the second ring heteroatom, when present, is independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; and wherein the heterocyclyl is optionally substituted with from 1-3 substituents independently selected from the group consisting of halogen, cyano, oxo, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy, and —N(R′)R′; or heteroaryl including from 5 to 6 ring atoms; wherein the heteroaryl includes not more than four ring heteroatoms (including the nitrogen atom attached to R4 and R5), and each additional ring heteroatom, when present, is independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; and wherein the heteroaryl is optionally substituted with from 1-3 substituents independently selected from the group consisting of halogen, cyano, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy, and —N(R′)R′; R6 is selected from the group consisting of —OH, C1-C6 alkoxy, —OC(O)—C1-C6 alkyl, —OC(O)phenyl, and —N(R′)R′; and R7 is H or C1-C6 alkyl. |
