| 摘要 |
Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula:;
wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided. |
| 主权项 |
1. A compound of the formula: wherein:
n is 0-3;Ar is heteroarenediyl(C≦8) or a substituted version thereof; andY is:
hydrogen, hydroxy, halo, amino, or cyano or —NCO; oralkyl(C≦8), alkenyl(C≦8), alkynyl(C≦8), aryl(C≦12), aralkyl(C≦12), heteroaryl(C≦8), heterocycloalkyl(C≦12), acyl(C≦12), alkoxy(C≦8), aryloxy(C≦12), acyloxy(C≦8), alkylamino(C≦8), dialkylamino(C≦8), arylamino(C≦8), aralkylamino(C≦8), alkylthio(C≦8), acylthio(C≦8), alkylsulfonylamino(C≦8), or substituted versions of any of these groups; or a pharmaceutically acceptable salt thereof. |
