ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES

摘要

The present invention concerns the radiolabelled compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is O or S; n is 2, 3, 4 or 5; R<1> is hydrogen, C1-6alkyl, C1-6alkyloxy or halo; R<2> is hydrogen, C1-6alkyl, phenyl, phenylC1-6alkyl or phenylcarbonyl; R<3> and R<4> each independently are selected from hydrogen, halo, nitro, C1-6alkyl, C1-6alkyloxy, haloC1-6alkyl, aminosulfonyl, mono- or di(C1-4alkyl)aminosulfonyl; or R<3> and R<4> may also be taken together to form a bivalent radical of formula -CH=CH-CH=CH- , characterized in that the compound has at least one halo which is a radioactive isotope of iodine, bromine or fluorine, or has at least one <11>C-atom or tritium atom ; it further relates to a process of marking dopamine D4 receptor sites and a process for imaging an organ.