PHOTO-PATTERNABLE OPTICAL LUMINESCENCE DUAL SENSORS AND METHODS OF PREPARING AND USING THEM

摘要

The present disclosure relates to an optical luminescence dual sensor comprising a polymerized form of a probe for sensing pH; a polymerized form of a probe for sensing oxygen; a polymerized form of an internal reference probe; and a matrix. The present disclosure also relates to methods of preparing an optical luminescence dual sensor and methods of using them.

主权项

1. An optical luminescence dual sensor comprising a copolymer, wherein the copolymer comprises:(a) a polymerized form of a probe for sensing pH;(b) a polymerized form of a probe for sensing oxygen;(c) a polymerized form of an internal reference probe; and(d) a matrix comprising a polymer selected from the group consisting of poly(2-hydroxyethyl methacrylate) (PHEMA), polyacrylamide (PAM), poly(poly(2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate)) (POEGMA), poly(N-isopropyl acrylamide) (PNIPAAm), and copolymers thereof;wherein:
the probe for sensing pH has formula (I): wherein
R1 is CmH2mX or NHCOCmH2mY, where m is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 8 and 11;X is selected from the group consisting of:and
Y is selected from the group consisting of: (b) the probe for sensing oxygen has formula (II): where M is selected from Pt or Pd;R11 and R12 can be the same or different and are independently selected from the group consisting of H, halo, CH3, OCH3 and OC2H5;R3 and R4 can be the same or different and are independently selected from the group consisting of H, halo, CH3, OCH3 and OC2H5;R5 and R6 can be the same or different and are independently selected from the group consisting of H, halo, CH3, OCH3 and OC2H5;R7, R8, R9 and R10 can be the same or different and are independently selected from the group consisting of (CH2)pOH, O(CH2)pOH, NH(CH2)pOH, (CH2)pOM′A, O(CH2)pOM′A, NH(CH2)pOM′A, (CH2)pOA, O(CH2)pOA, NH(CH2)pOA, (CH2)pOVA, O(CH2)pOVA, NH(CH2)OVA, (OCH2CH2)qOH, NH(CH2CH2O)qH, (OCH2CH2)qOM′A, NH(CH2CH2O)qM′A, (OCH2CH2)qOH, NH(CH2CH2O)qA, (OCH2CH2)qOVA, NH(CH2CH2O)qVA,where
M′A is A is VA is p is an integer selected from the group of consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12; andc is an integer selected from the group of consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 38, 39, 40, 41, 42, 43, 44, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 and 150; and(c) the internal reference probe has formula (III): wherein R15, R16, R17, and R18 can be the same or different and are independently CnH2n+1, where n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7 and 8;X is an anion;Z is selected from the group consisting of: (CH2)pOH, O(CH2)pOH, NH(CH2)pOH, (CH2)pOM′A, O(CH2)pOM′A, NH(CH2)pOM′A, (CH2)pOA, O(CH2)pOA, NH(CH2)pOA, (CH2)pOVA, O(CH2)pOVA, NH(CH2)pOVA, (OCH2CH2)qOH, NH(CH2CH2O)qH, (OCH2CH2)qOM′A, NH(CH2CH2O)qM′A, (OCH2CH2)qOA, NH(CH2CH2O)qA, (OCH2CH2)qOVA, NH(CH2CH2O)qVA, CH2(OCH2CH2)rOA, CH2(OCH2CH2)rOM′A, CH2(OCH2CH2)rOVA; and
r is an integer selected from the group of consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 38, 39, 40, 41, 42, 43, 44, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149 and 150.