VACCINE AGAINST INFLUENZA H5N1 VIRUSES, MEDICAMENT AND TREATMENT OF H5N1 VIRAL INFECTIONS

摘要

The invention relates to an antigenic determinant (H5 epitope) of influenza hemagglutinin (H5N1 ) which is conserved over distant H5N1 lineages but not found in related hemagglutinins H1, H2 or H6; antibodies, antibody fragments and receptors against said conserved antigenic determinant of HA which have influenza A neutralizing activity as well as H5N1 specific vaccines on basis of said antigenic determinant. Methods for passive and active vaccinations are also disclosed, i.e. by administering a vaccine having said conserved H5 epitope as antigenic determinant or by administering an effective amount of antibodies against said antigenic determinant.