IMMUNOGENIC JC POLYOMAVIRUS COMPOSITIONS AND METHODS OF USE

摘要

Disclosed herein are methods of eliciting an immune response to a JC polyomavirus (JCV) by administering an effective amount of an immunogenic composition including an isolated JCV VP1 polypeptide or a nucleic acid encoding the VP1 polypeptide to a subject. VP1 polypeptides and immunogenic compositions suitable for use in the methods are disclosed herein, including JCV genotype 2 VP1 polypeptides and/or JCV genotype 3 polypeptides. Also disclosed are methods of identifying a subject at risk of developing progressive multifocal leukoencephalopathy (PML). In some embodiments, the methods include obtaining a biological sample from a subject, detecting presence or absence of JCV neutralizing antibodies in the sample from the subject, and identifying that the subject is at risk of developing PML if there is an absence of detectable JCV neutralizing antibodies in the sample from the subject.

主权项

1. A method of eliciting an immune response against a JC polyomavirus (JCV) in a subject, comprising administering to the subject an effective amount of an immunogenic composition comprising an isolated JCV genotype 2 VP1 polypeptide, an isolated JCV genotype 3 VP1 polypeptide, or a combination thereof, or an isolated nucleic acid encoding the VP1 polypeptide(s), thereby eliciting an immune response to JCV.