发明名称 |
SRM/MRM ASSAY FOR THE FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) PROTEIN |
摘要 |
Methods are provided for quantifying the fibroblast growth factor receptor 2 protein (FGFR2) directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM)/Multiple Reaction Monitoring (MRM) mass spectrometry. The biological sample may be selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells. A protein sample is prepared from the biological sample and the FGFR2 protein is quantitated in the sample using the method of SRM/MRM mass spectrometry by quantitating in the protein sample at least one fragment peptide derived from FGFR2. |
申请公布号 |
WO2016183597(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
WO2016US32794 |
申请日期 |
2016.05.16 |
申请人 |
EXPRESSION PATHOLOGY, INC. |
发明人 |
KRIZMAN, David, B.;HEMBROUGH, Todd;THYPARAMBIL, Sheeno;LIAO, Wei-li |
分类号 |
G01N33/68;G01N33/48;G01N33/574 |
主分类号 |
G01N33/68 |
代理机构 |
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