| 发明名称 | Gamma-AApeptides with potent and broad-spectrum antimicrobial activity | ||
| 摘要 | The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms. | ||
| 申请公布号 | US9499587(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201314374018 | 申请日期 | 2013.01.23 |
| 申请人 | UNIVERSITY OF SOUTH FLORIDA | 发明人 | Cai Jianfeng;Niu Youhong;Wu Haifan;Padhee Shruti |
| 分类号 | A61K38/04;C07K5/12;A61K38/00;A61K38/12;C07K7/64;A61K38/08;G01N33/569;A61K45/06;A61K49/00;C07K7/06 | 主分类号 | A61K38/04 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A γ-AApeptide of the following structure: | ||
| 地址 | Tampa FL US | ||