PROCESS FOR THE PURIFICATION OR ISOLATION OF (2S, 3R)-1-HALO-2-HYDROXY-3-(PROTECTED AMINO)-4-PHENYLTHIOBUTANES OR OPTICAL ANTIPODES THEREOF

摘要

The present invention has for its object to provide a commercially useful, expedient and efficient method for purification and isolation of an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1) or its enantiomer, which is capable of removing the various contaminants, particularly said byproducts, whereby the problem of instability of the compound (1) or its enantiomer can be overcome and a high product yield can be insured. The present invention relates to a method of purifying and isolating an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1): (wherein X represents a halogen atom; one of P<1> and P<2> represents a hydrogen atom and the other represents an amino-protecting group, or P<1> and P<2> taken together represents an amino-protecting group) or its enantiomer, which comprises using an aromatic hydrocarbon solvent to remove impurities occurring in said compound (1) or impurities occurring in said enantiomer from said compound (1) containing impurities or its enantiomer containing impurities and isolate said compound (1) or said enantiomer as crystals.