DRUG DELIVERY SYSTEM COMPRISING MATRIX METALLOPROTEINASE INHIBITORS

摘要

A composition for topical application to a subjects skin comprising a matrix metalloproteinase inhibitor, more particularly an inhibitor selected from the group consisting of : TIMP-I, TIMP-2, TIMP-3, TIMP-4, Ilomastat, MMP inhibitor 111, CL82198, GM1489, and FN-439 is used for the prevention or treatment of soft skeletal tissue extracellular matrix degeneration, more particularly wherein the soft skeletal tissue is a tendon or ligament, and more particularly where the tendon is -selected from the group consisting of : superficial digital flexor tendon (SDFT), suspensory ligament, deep flexor tendon, deep digital flexor tendon (DDFT), accessory ligament of the deep digital flexor tendon, cruciate ligament, Achilles tendon, flexor tendon, quadriceps tendon, rotator cuff, and lateral or medial epichondylitis, and more particularly wherein the musculoskeletal injury or disorder is selected from superficial digital flexor tendinopathy and suspensory ligament desmitis, Achilles tendon injuries, rotator cuff injury, lateral epicondylitis, medial epicondylitis and patellar tendinopathy.