Apparatus comprising magnetically actuated valves and uses thereof

摘要

The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

主权项

1. A fluidic apparatus comprising:
a first reservoir comprising at least one first outlet; a first valve element; a first valve seat conformed to support the first valve element in a position that closes the first outlet and a layer of pressure sensitive adhesive deposited on at least a portion of the first valve seat such that the pressure sensitive adhesive layer is effective to releasably bond to a surface of the first valve element when the first valve element is seated in the outlet-closed position, wherein the first valve element is responsive to an applied magnetic field of sufficient strength by detaching from the first valve seat and undergoing a displacement that causes the first outlet to open.