USE OF ANTI-CD200 ANTIBODY FOR PROLONGING SURVIVAL OF ALLOGRAFTS

摘要

PROBLEM TO BE SOLVED: To provide use of anti-CD200 antibodies for prolonging the survival of allografts.SOLUTION: The present disclosure provides methods useful for prolonging the survival of an allograft organ in a recipient mammal. The above methods include administration of an anti-CD200 antibody or a CD200-binding fragment of the above antibody. The disclosure also provides biomarkers, a change in one or more biomarkers of which indicates that an anti-CD200 antibody has produced a desired immunomodulatory effect in a mammal. Also featured are pharmaceutical compositions, kits, and solutions that contain at least one anti-CD200 antibody and are useful in the methods described herein.SELECTED DRAWING: None