| 发明名称 |
QUINOLINE DERIVATIVES AS INHIBITORS OF HEAT SHOCK FACTOR 1 PATHWAY ACTIVITY |
| 摘要 |
The present invention relates to compounds of formula I, wherein R1, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them. |
| 申请公布号 |
WO2016156872(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
WO2016GB50938 |
申请日期 |
2016.04.01 |
| 申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
JONES, Keith;CHEESEMAN, Matthew;CHESSUM, Nicola;PASQUA, Elisa;EVANS, Lindsay;TUCKER, Michael;WILDING, Birgit;MOK, Ngai, Yi |
| 分类号 |
C07D405/12;A61K31/4709;A61P35/00 |
主分类号 |
C07D405/12 |
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