Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance

摘要

The present disclosure relates to a mucoadhesive composition, adapted for preventing and/or treating a pathological reaction of the immune system of an individual, by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm.

主权项

1. A method for treating allergy by enhancing the induction of a specific tolerance towards at least one allergen involved in said allergy, comprising:
administering, by the mucosal route, to an individual suffering from said allergy, a therapeutically effective quantity of a mucoadhesive composition comprising chitosan particles loaded with the at least one allergen involved in the allergy, said allergen being a protein, polypeptide or peptide, wherein the size of the loaded chitosan particles is from 1 μm to 3 μm and the chitosan particles are made of chitosan which viscosity is at least 800 cP, wherein the chitosan particles of the mucoadhesive composition enhance the induction of the specific tolerance towards the at least one allergen involved in said allergy, and wherein said allergen is selected from the group consisting of pollen allergens, mite allergens, insect allergens, animal hair and dandruff allergens, and food allergens.