VERSATILE CANINE INFLUENZA VIRUS VACCINE COMPOSITION

摘要

The present invention relates to a versatile canine influenza virus vaccine composition using the HA2 helical domain of a hemagglutinin protein, which is an influenza surface protein, and to a pharmaceutical composition for preventing or treating canine influenza virus infectious diseases. The polypeptide represented by SEQ ID NO: 3 and the polypeptide expressed by residues 379 to 474 of SEQ ID NO: 1 of the present invention can be mass-produced in E. coli, effectively produce neutralizing antibodies to various canine influenza virus subtypes, and boost an immune induction effect of the existing canine influenza vaccine through combined administration, and thus the polypeptides can be widely utilized as versatile vaccines for influenza virus subtypes and new influenza virus variants.