PROCOLLAGEN ASSEMBLY

摘要

A method of producing a desired procolagen or derivative thereof in a system which co-expresses and assembles at least one further procollagen or derivative thereof. The gene(s) for expressing pro- alpha chains or derivatives thereof for assembly into the desired procollagen has or have been exogenously selected from natural pro- alpha chains or exogenously manipulated such as to express said pro- alpha chains or derivatives thereof with domains which have the activity of C-terminal propeptide domains but which will not co-assemble with the C-terminal propeptide of the pro- alpha chains or derivatives thereof that assemble to form the said at least one further procollagen or derivative thereof.