| 发明名称 |
ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER |
| 摘要 |
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. |
| 申请公布号 |
US2016200833(A1) |
申请公布日期 |
2016.07.14 |
| 申请号 |
US201615067024 |
申请日期 |
2016.03.10 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Amann Maria;Bruenker Peter;Claus Christina;Ferrara Koller Claudia;Grau-Richards Sandra;Klein Christian;Levitsky Victor;Moessner Ekkehard;Regula Joerg Thomas;Umana Pablo |
| 分类号 |
C07K16/40;C07K16/28;C07K14/705 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A TNF family ligand trimer-containing antigen binding molecule comprising
(a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecule is characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or a fragment thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. |
| 地址 |
Little Falls NJ US |
