Macromolecular complex of bacterial origin and use of said macromolecular complex for preventing and treating inflammatory rheumatism

摘要

A bacterial macromolecular complex produced by bacteria belonging to the Bifidobacterium longum strain deposited according to the treaty of Budapest under number CNCM I-3994 with the Collection Nationale de Cultures de Microorganismes (CNCM) [National Collection of Microorganism Cultures], consisting of chains combining a lipoprotein and an oligosaccharide, wherein:
the lipoprotein has a molecular weight of from 30 kDa to 60 kDa;the oligosaccharide has a molecular weight of less than 15 kDa, and preferably less than 10 kDa;the lipoprotein component, which consists of all the lipoproteins of each of the chains, represents from 75 to 99%, preferentially from 80 to 98%, more preferentially from 85 to 95% by weight of the total weight of the complex, and the oligosaccharide component, which consists of all the oligosaccharides combined with each of the chains, represents from 1 to 25%.

主权项

1. An isolated bacterial macromolecular complex produced by the Bifidobacterium longum strain deposited according to the treaty of Budapest under number CNCM 1-3994, on May 23, 2008, with the Collection Nationale de Cultures de Microorganismes (CNCM) in a culture medium comprising native or hydrolyzed whey proteins, lactose and an antioxidant, the macromolecular complex comprising one or more chains comprising a combination of a lipoprotein and an oligosaccharide, wherein:
the lipoprotein has a molecular weight of from 30 kDa to 60 kDa; the oligosaccharide has a molecular weight of less than 15 kDa; the macromolecular complex has a molecular weight of greater than 150 kDa; and the total amount of lipoprotein is from 75 to 99% by weight of the total weight of the complex, and thetotal amount of oligosaccharide is from 1 to 25% of the total weight of the complex.