5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same

摘要

The invention provides 5-deuterium-enriched 2,4-thiazolidinediones (e.g., 5-[4-[2-(5-ethyl-2-pyridyl)-2-oxoethoxy]benzyl]-5-deutero-thiazolidine-2,4-dione), deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same.

主权项

1. A deuterium-enriched compound of formula VI or a stereoisomer or pharmaceutically acceptable salt form thereof: wherein: Z is H or D, provided that the abundance of deuterium in Z is at least 30%; RA is C1-4 alkoxy.