| 主权项 |
1. A method for treating a patient having an autoimmune or inflammatory disease comprising administering to said patient a therapeutically effective amount of an antibody that specifically binds to CD37 or antigen-binding fragment thereof, wherein said antibody or antigen-binding fragment comprises a heavy chain variable region and a light chain variable region, wherein the CDR1, CDR2, and CDR3 of said heavy chain variable region and the CDR1, CDR2, and CDR3 of said light chain variable region comprise the polypeptide sequences of:
(a) SEQ ID NOs: 4, 5, and 6 and SEQ ID NOs: 28, 29, and 30, respectively; (b) SEQ ID NOs: 7, 8, and 9 and SEQ ID NOs: 31, 32, and 33, respectively; (c) SEQ ID NOs: 10, 11, and 12 and SEQ ID NOs: 34, 35, and 36, respectively; (d) SEQ ID NOs: 13, 14, and 15 and SEQ ID NOs: 37, 38, and 39, respectively; (e) SEQ ID NOs: 13, 14, and 15 and SEQ ID NOs: 37, 40, and 39, respectively; (f) SEQ ID NOs: 16, 17, and 18 and SEQ ID NOs: 41, 42, and 43, respectively; (g) SEQ ID NOs: 19, 20, and 21 and SEQ ID NOs: 44, 45, and 46, respectively; (h) SEQ ID NOs: 19, 20, and 21 and SEQ ID NOs: 44, 47, and 46, respectively; (i) SEQ ID NOs: 22, 23, and 24 and SEQ ID NOs: 48, 49, and 50, respectively; (j) SEQ ID NOs: 22, 23, and 24 and SEQ ID NOs: 48, 51, and 50, respectively; or (k) SEQ ID NOs: 25, 26, and 27 and SEQ ID NOs: 52, 53, and 54, respectively. |
