| 发明名称 | Hydrogels for delivery of therapeutic polypeptides | ||
| 摘要 | Disclosed herein is a hydrogel composition comprising a polymer covalently linked to glutathione (GSH). Also disclosed herein is a method for providing localized delivery of one or more agents in a subject suffering from a disease. The method comprises administering to the subject a GST/GSH affinity hydrogel comprising a therapeutically effective amount of the one or more agents. | ||
| 申请公布号 | US9457101(B2) | 申请公布日期 | 2016.10.04 |
| 申请号 | US201314405701 | 申请日期 | 2013.06.06 |
| 申请人 | The Board of Trustees of the University of Illinois | 发明人 | Gemeinhart Richard;Buhrman Jason;Rayahin Jamie |
| 分类号 | A61K38/00;A61B6/00;A61K47/48;A61K9/06;A61K49/00;A61K47/32 | 主分类号 | A61K38/00 |
| 代理机构 | Botkin & Hall, LLP | 代理人 | Botkin & Hall, LLP |
| 主权项 | 1. A hydrogel composition for in vivo drug delivery comprising: a polymer covalently linked to glutathione (GSH) with therapeutic polypeptide molecules bound to the hydrogel by glutathione S-transferase (GST) fusion partners. | ||
| 地址 | Urbana IL US | ||