Delivery of ibuprofen and other compounds

摘要

The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt, a nitric oxide donor, and optionally, a hostile biophysical environment. In some cases, the composition may be stabilized using a stabilization polymer such as xanthan gum, KELTROL® BT and/or KELTROL® RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20, which unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

主权项

1. A composition for topical delivery to the skin of a subject, the composition comprising:
an ionic strength of at least about 0.25 M; a stabilization polymer comprising xanthan gum; propylene glycol; a polysorbate surfactant; and ibuprofen and/or an ibuprofen salt.