Modified foot and mouth disease virus (FMDV) VP1 capsid protein

摘要

The present invention provides a foot-and-mouth diseases virus (FMDV) VP1 capsid protein which comprises an entity of interest (EOI). The EOI sequence may, for example, be an epitope tag, an immunomodulatory molecule or a target molecule. The present invention also provides an FMDV vaccine which comprises such a VP1 capsid protein and its use to prevent FMD.

主权项

1. A foot-and-mouth disease virus (FMDV) particle or virus-like particle which comprises a VP1 capsid protein which comprises an entity of interest (EOI) inserted within or attached to the G-H loop, wherein the EOI is inserted or attached downstream of the motif RGDXXXX (where X is any amino acid) within the G-H loop of the VP1 capsid protein and wherein the EOI is an epitope tag.