| 主权项 |
1. A method for treatment of chronic renal failure comprising orally administering a therapeutically effective amount of a 4,8-inter-m-phenylene prostaglandin I2 derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof:wherein:
R1 represents COOR2 wherein R2 represents hydrogen or a pharmacologically acceptable positive ion; A represents:
1) —(CH2)m—; or2) —CH2—CH═CH—
wherein in represents 3; Y represents hydrogen; B represents —X—C(R11)(R12)OR13 wherein each of R11 and R13 represents hydrogen; X represents:
1) —CH═CH—; or2) —C≡C—; and R12 represents:
1) —Z—Ar2;2) —Z—R3; or3) —CuH2u—C≡C—R17 wherein Z represents a valence bond; Ar2 represents phenyl; R3 represents cyclohexyl; u represents 3; CuH2u represents a branched alkylene group; and R17 represents methyl; E represents —OH; and the formula (I) represents a d-form, l-form or dl-form,to a patient with chronic renal failure, wherein said chronic renal failure in said patient has advanced and is characterized by:
a) Blood urea nitrogen (BUN) of 60 mg/dl or higher, b) Congestive heart failure or lung congestion associated with reduced urinary volume, c) Neurological or mental complaints associated with advanced uremia, d) Hyponatremia or hyperkalemia, e) Anemia caused by reduced production of erythropoietin in the kidney, or f) Uremic symptoms caused by the advanced disorders or renal function. |
