Compositions and methods for increasing insulin sensitivity

摘要

Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains one or more of an opioid antagonist, an anticonvulsant, and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level. In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.

主权项

1. A method of treating insulin resistance, comprising:
identifying a subject having a blood-glucose condition characterized by insulin resistance in need of treatment, wherein the condition is Type 2 diabetes and the subject is treated with insulin; and administering to the subject an amount of a composition that is effective to treat the insulin resistance, wherein the composition comprises naltrexone or a pharmaceutically acceptable salt thereof and bupropion or a pharmaceutically acceptable salt thereof, wherein the amount of the naltrexone or pharmaceutically acceptable salt thereof is about 25 mg per day to about 50 mg per day, and wherein the amount of the bupropion or pharmaceutically acceptable salt thereof is about 200 mg per day to about 400 mg per day; obtaining a measurement of the subject's blood glucose level following treatment with said composition; and decreasing the amount of insulin used in the insulin treatment in response to the measurement of the subject's blood glucose level following treatment with said composition.