发明名称 |
TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY |
摘要 |
Templates-fixed .beta.-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy. |
申请公布号 |
CA2598360(C) |
申请公布日期 |
2016.12.20 |
申请号 |
CA20052598360 |
申请日期 |
2005.02.17 |
申请人 |
POLYPHOR LTD.;UNIVERSITAT ZURICH |
发明人 |
DEMARCO, STEVEN J.;MOEHLE, KERSTIN;HENZE, HEIKO;SELLIER, ODILE;JUNG, FRANCOISE;GOMBERT, FRANK;OBRECHT, DANIEL;LUDIN, CHRISTIAN |
分类号 |
C07K7/06;A61K38/04;C07K7/08;C07K7/64 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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