发明名称 |
Strategies for Designing Drugs that Target the Sir2 Family of Enzymes |
摘要 |
The instant invention describes methods of identifying compounds that modulate the activity of Sir2 enzymes. Sir2 enzymes form a unique class Of NAD+ dependent deacetylases required for diverse biological processes including transcriptional silencing, regulation of apoptosis, fat mobilization, and lifespan regulation. Sir2 activity is regulated by nicotinamide, a non-competitive inhibitor that promotes a base exchange reaction at the expense of deacetylation.
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申请公布号 |
US2009012130(A1) |
申请公布日期 |
2009.01.08 |
申请号 |
US20060883015 |
申请日期 |
2006.01.25 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
WOLBERGER CYNTHIA;AVALOS JOSE L. |
分类号 |
A61K31/4406;A61P35/00;C12Q1/34 |
主分类号 |
A61K31/4406 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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