发明名称 |
MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET, AND USE THEREOF |
摘要 |
A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide,
Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (1) (SEQ ID NO. 1)
Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH 2 (2) (SEQ ID NO. 2)
B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH 2 (3) (SEQ ID NO. 3)
where, in formulae (1) and (2), "X" represents a lysine residue, the amino group of the side chain of the lysine residue being labeled with a radioactive nuclide, and "Z-" indicates that the ±-amino group at the N-terminus is not modified, or is modified with a modifying group having no electric charge; in formula (3), "B-" indicates that the ±-amino group at the N-terminus is labeled with a radioactive nuclide; and in formulae (1), (2), and (3), "-NH 2 " indicates that the carboxyl group at the C-terminus is amidated. |
申请公布号 |
EP2510951(B1) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20100836003 |
申请日期 |
2010.12.08 |
申请人 |
KYOTO UNIVERSITY;ARKRAY, INC. |
发明人 |
SAJI, HIDEO;INAGAKI, NOBUYA;TOYODA, KENTARO;KIMURA, HIROYUKI;HIRAO, KONOMU;NAGAKAWA, KENJI;MATSUDA, HIROKAZU |
分类号 |
A61K51/08;C07K1/13;C07K14/605;G01N33/74;G01T1/161 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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