主权项 |
1. A method of treating cancer, an autoimmune disease or infectious disease, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula Iwherein
R1 is C1-7-alkyl or C1-7-alkoxy-C1-7-alkyl; R2 is selected from the group consisting of hydrogen, halogen, hydroxyl, hydroxy-C1-7-alkyl, alkoxy-C1-7-alkyl, carboxyl, carboxyl-C1-7-alkyl, carboxyl-C2-7-alkenyl, aminocarbonyl-C1-7-alkyl, aminocarbonyl-C2-7-alkenyl, C1-7-alkylamino-carbonyl-C1-7-alkyl, C1-7-alkylamino-carbonyl-C2-7-alkenyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkoxycarbonyl-C2-7-alkenyl, C1-7-alkyl-sulfonyl-C1-7-alkyl, sulfamoyl-C1-7-alkyl, C1-7-alkyl-sulfamoyl-C1-7-alkyl,
phenyl, said phenyl being unsubstituted or substituted with one, two or three groups selected from the group consisting of C1-7-alkyl, C1-7-cycloalkyl, halogen, halogen-C1-7-alkyl, halogen-C1-7-alkoxy, hydroxy, hydroxy-C1-7-alkyl, C1-7-alkoxy, cyano, carboxyl, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkylsulfonyl, hydroxy-C1-7-alkylsulfonyl, C1-7-alkoxy-C1-7-alkylsulfonyl, carboxyl-C1-7-alkylsulfonyl, C1-7-alkoxy-carbonyl-C1-7-alkylsulfonyl, amino, C1-7-alkylamino, di-C1-7-alkylamino and nitro, andphenoxy, said phenoxy group being unsubstituted or substituted with one, two or three groups selected from the group consisting of C1-7-alkyl, C1-7-cycloalkyl, halogen, halogen-C1-7-alkyl, halogen-C1-7-alkoxy, hydroxy, hydroxy-C1-7-alkyl, C1-7-alkoxy, cyano, carboxyl, C1-7-alkoxycarbonyl, C1-7-alkoxycarbonyl-C1-7-alkyl, C1-7-alkyl-sulfonyl, hydroxy-C1-7-alkylsulfonyl, C1-7-alkoxy-C1-7-alkylsulfonyl, carboxyl-C1,7-alkylsulfonyl, C1-7-alkoxy-carbonyl-C1-7-alkylsulfonyl, amino, C1-7-alkylamino, di-C1-7-alkylamino and nitro; R3 is hydrogen or halogen; R4 is selected from the group consisting of
—O—(CH2)m-NHR5, and—O—(CO)—(CH2)n-NHR6,wherein
m is selected from 1, 2 or 3,n is selected from 1 or 2,R5 is selected from the group consisting of hydrogen, hydroxy-C1-7-alkyl, amino-C1-7-alkyl, C1-7-alkylcarbonyl, phenylcarbonyl, heteroarylcarbonyl, carboxyl, carboxyl-C1-7-alkyl and C1-7- alkoxycarbonyl-amino-C1-7-alkyl-carbonyl, andR6 is selected from the group consisting of hydrogen, hydroxy-C1-7-alkyl, amino-C1-7-alkyl, C1-7-alkylcarbonyl, phenylcarbonyl, heteroarylcarbonyl, carboxyl, carboxyl-C1-7-alkyl and C1-7- alkoxycarbonyl-amino-C1-7-alkyl-carbonyl,or a pharmaceutically acceptable salt thereof. |