| 主权项 |
1. A compound of Formula I: wherein A is aryl or heteroaryl optionally substituted with C1-C4 alkyl, halogen, OH, CN, or N(R4)2; R1 is absent, H, OH, halogen, N(R4)2, or C1-C4 alkyl optionally substituted with halogen, OH, O-alkyl, CN, or N(R4)2; R2 and R3 are independently H, halogen, or C1-C4 alkyl optionally substituted with halogen, OH, CN, N(R4)2, or R2 and R3, taken together may form a 4-7 membered saturated or unsaturated ring, optionally incorporating 0-3 N, O, or S atoms; wherein the 4-7 membered ring is optionally substituted with C1-C4 alkyl, halogen, OH, carbonyl, CN, halogen, or N(R4)2, or R2 and R3, can be taken together to form a carbonyl; Each R4 is independently H, alkyl, or aryl, or two R4 can be taken together to form a 4-7 membered ring, optionally incorporating 0-3 N, O, S atoms; wherein the 4-7 membered ring is optionally substituted with C1-C4 alkyl, halogen, OH, CN, halogen, or N(R4)2; Each R5 is independently H or alkyl, or both R5 can be taken together to form a carbonyl; Y is 5-7 membered heteroaromatic ring linked via a carbon atom and optionally substituted, selected from unsubstituted thienyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted isoxazolyl, substituted or unsubstituted isothiazolyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted pyrazolyl, substituted or unsubstituted oxadiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted pyridinyl, substituted or unsubstituted pyrimidinyl, substituted or unsubstituted pyrazinyl, substituted or unsubstituted pyridazinyl, and substituted or unsubstituted triazinyl; n is 0, or 1; o is 0 or 1; p is 1 or 2; and wherein the symbol indicates a single or double bond; or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, and tautomer thereof. |
