Emulsion-based process for preparing microparticles and workhead assembly for use with same

摘要

The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.

主权项

1. A process for making microparticles, comprising:
(a) providing a process stream comprising (i) a dispersed phase comprising a first solvent having a polymer and an agent dissolved or dispersed therein; and (ii) a continuous phase comprising a second solvent that is partially or totally immiscible in the first solvent; (b) passing the process stream through a screen and into a mixing environment, without a subsequent screen or perforated stator in the mixing environment; such that during step (a) and/or (b), an emulsion forms that comprises microdroplets of the dispersed phase in the continuous phase; (c) at least substantially removing the first solvent from the microdroplets to form the microparticles; and wherein the process is performed without high-shear mixing, wherein the process stream is not subsequently screened in the mixing environment.