Hydrogel filaments for biomedical uses

摘要

Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

主权项

1. A method for preparing a device for implantation comprising:
combining a difunctional, low molecular weight ethylenically unsaturated macromer, an ethylenically unsaturated monomer, a visualization agent selected from barium, a barium salt, gadolinium, iron oxide, or an aromatic ring including at least one iodine atom, and a solvent to prepare a prepolymer solution; preparing a hydrogel filament having a buckling force of 0.5±0.4 gf from the prepolymer solution, and attaching the hydrogel filament to a coupler, wherein the coupler is configured to attach to a delivery pusher, wherein the device has no support members, and wherein the difunctional, low molecular weight ethylenically unsaturated macromer comprises polyethylene glycol, propylene glycol, poly(tetramethylene oxide), poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, derivatives thereof, or combinations thereof.