发明名称 |
METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL RECEPTOR |
摘要 |
Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population. |
申请公布号 |
EP3099708(A1) |
申请公布日期 |
2016.12.07 |
申请号 |
EP20150744002 |
申请日期 |
2015.01.28 |
申请人 |
University Health Network |
发明人 |
HIRANO, Naoto;NAKATSUGAWA, Munehide;OCHI, Toshiki |
分类号 |
C07K14/725;A61K38/17;C12N5/10;C12N15/09;C12N15/12;C12P21/02 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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