发明名称 |
Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
摘要 |
Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a prostate tumor to treatment with an Hh pathway antagonist.
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申请公布号 |
US2008095761(A1) |
申请公布日期 |
2008.04.24 |
申请号 |
US20040572430 |
申请日期 |
2004.10.01 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BEACHY PHILIP A.;BERMAN DAVID M.;KARHADKAR SUNIL S. |
分类号 |
A61K39/395;A61B;A61K31/35;A61K31/4355;A61K31/7105;A61K38/16;C07K16/00;C12N15/12;C12N15/85;C12N15/86;C12P21/00;C12Q1/02;C12Q1/48;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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