METHOD FOR INDIVIDUALIZED DRUG THERAPY

摘要

Methods for individualized therapy of arthritic pain using a non-steroidal anti-inflammatory drug (NSAID). Said methods comprise basing NSAID dose on each patient's pharmacokinetic and pharmacodynamic response to said NSAID.

主权项

1. A method for individualized therapy of arthritic pain using celecoxib, comprising:
a. orally administering a first celecoxib formulation comprising 100 mg of celecoxib to a patient suffering from arthritic pain; b. determining the celecoxib concentration in the patient's blood at a plurality of time points after the first celecoxib formulation was administered to the patient; c. transforming the patient's celecoxib concentration/time data points in to one or more pharmacokinetic (PK) parameters; d. determining the patient's clinical response to the first celecoxib formulation comprising 100 mg of celecoxib and
i. if pain control is not adequate repeat steps a-c with a higher celecoxib dose;ii if toxicity is not tolerable repeat steps a-c with a lower celecoxib dose;iii. if pain control is adequate and toxicity is tolerable determine the then present value for one or more pharmacokinetic (PK) parameters; and e. maintaining the patient on the celecoxib formulation at a celecoxib dose and frequency of administration that results in the value for the one or more pharmacokinetic (PK) parameters determined in step d (iii).