| 主权项 |
1. An antiemetic system for weekly application, comprising two identical transdermal patches, a first patch and a second patch, each of which has a skin-contacting area of 20-70 cm2 and includes:
a backing layer, a release liner, and a matrix layer, disposed between the backing layer and the release liner, containing Granisetron 3-6% by weight of the matrix layer, wherein the first patch is administered to a subject for 3 days followed by administering the second patch to the subject for 4 days, the system thereby providing a dose-proportional area under curve (AUC) of plasma Granisetron and, for every 10 cm2 skin-contacting area, delivering 1-4 mg of Granisetron in 7 days with a daily AUC of plasma Granisetron at 26.3±4.0 ng*hr/ml for each of days 2 to 7 of the administration. |
