Tri modal spectroscopic imaging

摘要

The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.

主权项

1. A spectroscopic imaging system comprising:
a light source system including a broadband light source and a laser light source for inducing tissue autofluorescence; an optical scanning system configured to optically couple light from the light source system across a scanning region that is positioned to receive scanning light that is incident on an illumination area within the scanning region, the optical scanning system including a moveable mirror device; a fiber optic device optically coupling light from the light source system to the optical scanning system, the fiber optic device having a proximal end and a distal end; an imaging detector optically coupled to a proximal end of the fiber optic device such that the imaging detector detects autofluorescent light and reflectance light to provide autofluorescence image data and reflectance image data; the moveable mirror device providing relative movement between light emitted from a distal end of the fiber optic device and the scanning region, the optical scanning system optically coupling light received from the scanning region by the moveable mirror device into a plurality of collection optical fibers of the fiber optic device, the proximal end of the plurality of collection optical fibers being optically coupled to the imaging detector for acquiring images of tissue; and a data processor connected to the imaging detector that processes the autofluorescence image data and reflectance image data to generate a diagnosis.