| 发明名称 | Cloning of honey bee allergen | ||
| 摘要 | The present invention relates to a recombinant polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera having a homology of more than 70% to the amino acid sequence of SEQ ID NO: 2, which is the honey bee allergen Api m3 (acid phosphatase). The invention further relates to nucleic acid encoding the polypeptide, expression vectors, host cells and methods of preparing the polypeptide, as well as diagnostic and pharmaceutical uses thereof. | ||
| 申请公布号 | US9446121(B2) | 申请公布日期 | 2016.09.20 |
| 申请号 | US200912404168 | 申请日期 | 2009.03.13 |
| 申请人 | PLS-DESIGN GMBH | 发明人 | Grunwald Thomas |
| 分类号 | A61K38/00;A61K38/04;A61K39/00;A61K39/35;A61K39/36;C07K1/00;C07K2/00;C07K4/00;C07K5/00;C07K7/00;C07K14/00;C07K16/00;C07K14/435 | 主分类号 | A61K38/00 |
| 代理机构 | Mayer & Williams PC | 代理人 | Wieczorek Ann;Mayer & Williams PC |
| 主权项 | 1. A recombinant polypeptide capable of binding to an IgE from subjects allergic to venom of an insect from the order Hymenoptera, wherein said polypeptide is expressed in E. Coli, High5 or Sf9 cells and has the amino acid sequence of SEQ ID NO: 2. | ||
| 地址 | Hamburg DE | ||