| 摘要 |
PROBLEM TO BE SOLVED: To provide a therapeutic agent having a wider applicable range and higher effect by improving antisense oligonucleotide to an SES (splicing enhancer sequence) that exists in exons 19, 41, 45, 46, 44, 50, 55, 51 or 53 of a dystrophin gene.SOLUTION: There is provided an oligonucleotide having a base sequence complementary to nucleotide number 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601, 2575-2592 or the like of a dystrophin cDNA (Gene Bank accession No. NM_004006.1), and a muscular dystrophy therapeutic agent containing the same.SELECTED DRAWING: None |
