TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF

摘要

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

主权项

1. A nucleic acid comprising:
a. a first polynucleotide encoding a target-specific ligand; b. a second polynucleotide encoding a ligand that binds a protein associated with the TCR complex; and c. a third polynucleotide encoding a T cell receptor signaling domain polypeptide.