| 主权项 |
1. A method of treating lung cancer or lymphoma in an individual, comprising administering to the individual a therapeutically effective amount of an antibody, or antigen-binding fragment thereof, which binds Extra Domain-A (ED-A) of fibronectin comprising a VH domain and a VL domain:
wherein the VH domain comprises a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, wherein:
HCDR1 has amino acid sequence SEQ ID NO: 83;HCDR2 has amino acid sequence SEQ ID NO: 4; andHCDR3 has amino acid sequence SEQ ID NO: 5; and wherein the VL domain comprises a framework and a set of complementarity determining regions LCDR1, LCDR2 and LCDR3, wherein:
LCDR1 has amino acid sequence SEQ ID NO: 86;LCDR2 has amino acid sequence SEQ ID NO: 7; andLCDR3 has amino acid sequence SEQ ID NO: 8; andwherein the antibody is conjugated to a molecule that has biocidal or cytotoxic activity or is conjugated to a radioisotope. |
