SPECIFIC MONITORING METHOD FOR OBSERVING A TREATMENT COMPRISING AN INHIBITOR OF THE ANGIOTENSIN-CONVERTING ENZYME

摘要

The invention concerns a specific monitoring method for observing a treatment comprising an inhibitor of the angiotensin-converting enzyme (IEC) and the use of tetrapeptide N-acetyl Ser-Asp-Lys-Pro (acetyl-SDKP or Ac-SDKP), as specific and 100 % reliable marker when evaluating the observance of a treatment comprising an IEC. This method consists in: the quantitative analysis of N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) in at least one sample of biological fluid, selected at least among plasma and urine of a person to be monitored; and quantifying the observance, considered to be positive, if the plasma concentration in Ac-SDKP is higher than 1.50 pmol/ml, and/or the urine concentration in Ac-SDKP is higher than 30 pmol/ml.