Method and apparatus for improving delivery of an agent to a kidney

摘要

Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.

主权项

1. A method comprising delivering a solution having a concentration of a therapeutic agent to an organ having branched vessels wherein delivering comprises at least one step that improves the therapeutic agent concentration uniformity among the branched vessels, wherein the step that improves the therapeutic agent concentration comprises normalizing a viscosity of the therapeutic agent solution towards that of blood such that a relative standard deviation measurement corresponding to the concentration uniformity of the therapeutic agent among the branched vessels is less than 29 percent.