Demineralized cancellous bone scaffolds

摘要

The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.

主权项

1. A cancellous bone scaffold configured for insertion into a calcified bone matrix to repair a soft connective tissue interface with a bone, the cancellous bone scaffold comprising a contiguous scaffold having a mineralized cancellous bone segment and a demineralized cancellous bone segment and at least one partially demineralized interface between the mineralized segment and the demineralized segment, the partially demineralized interface comprising 2% to 10% calcium, wherein both the mineralized segment and the demineralized segment are crosslinked, wherein the cancellous bone scaffold has been treated to remove osteoinductivity from at least the demineralized segment, and wherein the cancellous bone scaffold is capable of forming a direct or indirect insertion into a calcified bone matrix.