发明名称 |
Crystals and process of making 5-({[2-amino-3-(4-Carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
摘要 |
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. |
申请公布号 |
US9364489(B2) |
申请公布日期 |
2016.06.14 |
申请号 |
US201514806465 |
申请日期 |
2015.07.22 |
申请人 |
Forest Tosara Limited |
发明人 |
Anzalone Luigi;Villani Frank J.;Teleha Christopher A.;Feibush Penina;Fegely Barry |
分类号 |
A61K31/4164;C07D233/64;A61K31/625 |
主分类号 |
A61K31/4164 |
代理机构 |
Sheridan Ross P.C. |
代理人 |
Sheridan Ross P.C. |
主权项 |
1. A method of treating a mammal suffering from irritable bowel syndrome comprising administering to said mammal an effective amount of a Form α crystal of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. |
地址 |
Dublin IE |