Compositions of (-)-17-(cyclobutylmethyl)morphinan-3,14-diol

摘要

The present invention is directed to oral, therapeutically effective modified release pharmaceutical compositions of (−)-17-(cyclobutylmethyl)morphinan-3,14-diol and it pharmaceutically acceptable salts and the use thereof, including delayed onset and extended release dosage forms. The present invention is also directed at modified release dosage forms of oral (−)-17-(cyclobutylmethyl)morphinan-3,14-diol which provide robust efficacy and reduced potential for abuse and misuse.

主权项

1. An oral dosage form comprising: (i) a therapeutically effective amount of butorphanol, a pharmaceutically acceptable salt thereof, or a mixture thereof, and (ii) controlled release material to render said dosage form suitable for modified release of the butorphanol in a therapeutically effective manner following oral administration of the dosage form, wherein the dosage form provides first release of butorphanol in an anatomic region selected from the group consisting of the duodenum, the jejunum, the ileum, and the colon.