发明名称 |
COMBINATIONS OF INHIBITORS OF IRAK4 WITH INHIBITORS OF BTK |
摘要 |
The present application relates to novel combinations of at least two components, component A and component B: · component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; · component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, · one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis. |
申请公布号 |
WO2016174183(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
WO2016EP59576 |
申请日期 |
2016.04.29 |
申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT |
发明人 |
BOTHE, Ulrich;WENGNER, Antje Margret;SIEBENEICHER, Holger;SCHMIDT, Nicole;NUBBEMEYER, Reinhard;BÖMER, Ulf;GÜNTHER, Judith;STEUBER, Holger;LANGE, Martin;STEGMANN, Christian;SUTTER, Andreas;NEUHAUS, Roland |
分类号 |
A61K31/4439;A61K31/454;A61K31/496;A61K31/497;A61K31/4985;A61K31/505;A61K31/506;A61K31/519;A61K31/5377;A61K31/55;A61P35/00;A61P35/02;C07D401/12 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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