| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely to a method of producing a microencapsulated form of therapeutic peptide for oral application. Method involves administering undecapeptide U2 into lycopodium spores shells (LS) and further formation of alginate microcapsules (AMC) containing the said shell with peptide U2, for suppressing peptidase activity in the intestinal medium the system includes peptidases inhibitor - ovomucoid (OM), which is added to the alginate solution before the stage of forming AMC by ionotropic cross-linking, dispersion of LS with peptide U2 in water solution of sodium alginate and OM was injected in droplets into a settling bath containing an aqueous solution of CaCl, then filtered, washed with water and dried under certain conditions, dimensions of the AMC make 800-900 mcm, inclusions of U2 and OM therein make 20-30 mcg/ml and 10-20 mcg/mg, respectively.EFFECT: described method enables to obtain microencapsulated forms of therapeutic peptide for oral application in the form of two-level microcapsules having resistance to gastric acid medium and with prolonged release into the alkaline medium of the intestine.1 cl, 1 dwg, 1 ex |
