CO-CRYSTALS OF TRAMADOL AND NSAIDS

摘要

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
In a preferred embodiment, co-crystals of (-)tramadol-(S)-naproxen (1:2) and (+)tramadol-(R)-naproxen (1:2) are prepared.